Efficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study

作者：Xinyi Hong, Shanhu Qiu, Xia Wu, Sizhen Chen, Xiaoxiang Chen, Bei Zhang, Aiqin He, Yun Xu, Jianqing Wang, Yingchun Gao, Xizhong Xu, Li Sun, Yang Zhang, Libing Xiang, Jundong Zhou, Qun Guan, Yanling Zhu, Hai‐Yan Liu, Hao Xu, Ying Zhou, Bingwei Chen, Yang Shen · 发表于：Drug Design Development and Therapy · 年份：2023 · DOI：10.2147/dddt.s408304 · 被引用次数：10 · 研究领域：Lung Cancer Research Studies、Endometrial and Cervical Cancer Treatments、RNA modifications and cancer

Purpose: Anlotinib is a novel oral small-molecule multi-target tyrosine kinase inhibitor that has been approved for treating non-small cell lung cancer. However, its efficacy and safety among patients with advanced gynecological cancer have not been comprehensively evaluated. We conducted this study to address this issue in the real-world setting. Patients and Methods: Data from patients treated with Anlotinib for persistent, recurrent or metastatic gynecological cancer were collected from 17 centers from August 2018. The database lock-time was on March 2022. Anlotinib was administered orally on days 1-14 every 3 weeks until disease progression, severe toxicity occurred, or death. In this study, disease-specific advanced gynecological cancer was mainly referred to cervical, endometrial, and ovarian cancer. The outcomes included objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS). Results: A total of 249 patients were analyzed, with a median follow-up of 14.5 months. The overall ORR and DCR were 28.1% [95% confidence interval (CI) 22.6% to 34.1%] and 80.7% (95% CI 75.3% to 85.4%), respectively. Specifically, the ORR varied from 19.7% to 34.4% and the DCR differed from 81.7% to 90.0% in disease-specific advanced gynecological cancer. The median PFS was 6.1 months and ranged from 5.6 to 10.0 months in the overall and disease-specific advanced gynecological cancer, respectively. Larger cumulative dosage of Anlotinib (>700 mg) was in gene...