Aberrant dentato‐rubro‐thalamic pathway in action tremor but not rest tremor: A multi‐modality magnetic resonance imaging study

作者：Xiaojie Duanmu, Jiaqi Wen, Sijia Tan, Tao Guo, Cheng Zhou, Haoting Wu, Jingjing Wu, Zhengye Cao, Xiaocao Liu, Jingwen Chen, Chenqing Wu, Jianmei Qin, Luyan Gu, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu · 发表于：CNS Neuroscience & Therapeutics · 年份：2023 · DOI：10.1111/cns.14339 · 被引用次数：7 · 研究领域：Neurological disorders and treatments、Glycogen Storage Diseases and Myoclonus、Botulinum Toxin and Related Neurological Disorders

AIMS: The purpose of this study was to clarify the dentato-rubro-thalamic (DRT) pathway in action tremor in comparison to normal controls (NC) and disease controls (i.e., rest tremor) by using multi-modality magnetic resonance imaging (MRI). METHODS: This study included 40 essential tremor (ET) patients, 57 Parkinson's disease (PD) patients (29 with rest tremor, 28 without rest tremor), and 41 NC. We used multi-modality MRI to comprehensively assess major nuclei and fiber tracts of the DRT pathway, which included decussating DRT tract (d-DRTT) and non-decussating DRT tract (nd-DRTT), and compared the differences in DRT pathway components between action and rest tremor. RESULTS: Bilateral dentate nucleus (DN) in the ET group had excessive iron deposition compared with the NC group. Compared with the NC group, significantly decreased mean diffusivity and radial diffusivity were observed in the left nd-DRTT in the ET group, which were negatively correlated with tremor severity. No significant difference in each component of the DRT pathway was observed between the PD subgroup or the PD and NC. CONCLUSION: Aberrant changes in the DRT pathway may be specific to action tremor and were indicating that action tremor may be related to pathological overactivation of the DRT pathway.