SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes

作者：Liang Zeng, Zheng Wang, Xinglong Liu, Yuchuan Zhou, Xiaoya Jin, Yuqi Xiao, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao · 发表于：Theranostics · 年份：2023 · DOI：10.7150/thno.81999 · 被引用次数：33 · 研究领域：Lipid metabolism and disorders、Autophagy in Disease and Therapy、Caveolin-1 and cellular processes

The SDC1-TGM2-FLOT1-BHMT copolymer, a novel member of the protein complexes involved in the fusion of lysosomes and autophagosomes, maintained the autophagic flux in the irradiated tumor cells and ultimately enhanced radioresistance of GBM, which provides new insights of the molecular mechanism and therapeutic targets of radioresistant GBM.