Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression

作者：Hongjiang Li, Chao Yang, Yanfei Wei, Xueyuan Li, Jiang Wei, Yiran Xu, Lifeng Li, Rongqun Guo, Di Chen, Peng Gao, Haohao Zhang, Hui Qin, Zhenyu Zhang, Xianzhi Liu, Dongming Yan · 发表于：Theranostics · 年份：2023 · DOI：10.7150/thno.82975 · 被引用次数：44 · 研究领域：Ferroptosis and cancer prognosis、Immune cells in cancer、Extracellular vesicles in disease

Our study suggested that FTL promoted the development of an immunosuppressive TME by inducing M2 polarization in TAMs, and inhibition of FTL in TAMs reprogrammed the TME and sensitized glioma to anti-PD1 therapy, providing a new strategy for improving the therapeutic effect of anti-PD1.