Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life

作者：Huai-Yu Zhuchen, Jieyu Wang, Xiaoshan Liu, Yan‐Wei Shi · 发表于：Toxics · 年份：2023 · DOI：10.3390/toxics11070571 · 被引用次数：27 · 研究领域：Per- and polyfluoroalkyl substances research、Air Quality and Health Impacts、Toxic Organic Pollutants Impact

Per- and polyfluoroalkyl substances (PFASs) are widespread environmental pollutants. There is increasing evidence that PFASs have various adverse health effects, including renal toxicity, metabolic dysfunction, endocrine disruption, and developmental toxicity. PFASs have been found to accumulate in the placenta, and some PFASs can cross the placental barrier and subsequently accumulate in the fetus via the maternal-fetal circulation. An increasing number of studies have shown that early life exposure to PFASs can affect fetal neurodevelopment. This paper reviews the characteristics of indirect exposure to PFASs in early life, the effects on neurodevelopment in offspring, and the possible mechanisms of toxic effects.