The role of GPLD1 in chronic diseases

作者：Jing Cao, Anni Zhou, Zhuoyang Zhou, Hui Liu, Shaohui Jia · 发表于：Journal of Cellular Physiology · 年份：2023 · DOI：10.1002/jcp.31041 · 被引用次数：27 · 研究领域：Glycosylation and Glycoproteins Research、Protein Kinase Regulation and GTPase Signaling、Metabolism, Diabetes, and Cancer

Glycosylphosphatidylinositol-specific phospholipase D (GPLD1) is a specific enzyme for glycosylphosphatidylinositol (GPI) anchors, thereby exerting its biological functions by cleaving membrane-associated GPI molecules. GPLD1 is abundant in serum, with a concentration of approximately 5-10 µg/mL. Previous studies have demonstrated that GPLD1 plays a crucial role in the pathogenesis of numerous chronic diseases including disorders of lipid and glucose metabolism, cancer, and neurological disorders. In the present study, we reviewed the structure, functions, and localization of GPLD1 in chronic diseases, as well as exercise-mediated regulation of GPLD1, thus providing a theoretical support to develop GPLD1 as a new therapeutic target for chronic diseases.