Anaesthesia-related mortality within 24 h following 9,391,669 anaesthetics in 10 cities in Hubei Province, China: a serial cross-sectional study

作者：Yu Wang, Yu Wang, Jie Wang, Xihong Ye, Rui Xia, Ran Ran, Yaohua Wu, Qinghong Chen, H. Li, Shiqian Huang, Aihua Shu, Longqiu Yang, Bin Qin, WenLi Dong, Zhongyuan Xia, Zongze Zhang, Li Wan, Xiaohong Peng, Juying Liu, Zaiping Wang, Yanlin Wang, Yanlin Wang, Peng Yin, Xiangdong Chen, Shanglong Yao · 发表于：The Lancet Regional Health - Western Pacific · 年份：2023 · DOI：10.1016/j.lanwpc.2023.100787 · 被引用次数：18 · 研究领域：Cardiac, Anesthesia and Surgical Outcomes、Trauma and Emergency Care Studies、Sepsis Diagnosis and Treatment

Background: The mortality risk related to anaesthesia in China remains poorly characterized. The objective of this study was to evaluate the anaesthesia-related mortality in terms of its incidence, changes, causes and preventability in Hubei, China, between 2017 and 2021 using a series of annual surveys. Methods: We prospectively collected information on patient, surgical, anaesthesia, and hospital characteristics for 9,391,669 anaesthesia procedures performed between 2017 and 2021 in 10 cities within Hubei Province, China. Anaesthesia-related death was defined as death that deemed to be entirely or partially attributable to anaesthesia, occurring within 24 h following anaesthesia administration. All fatalities were scrutinized consecutively to determine their root causes and preventability. The incidence and patterns of anaesthesia-related deaths were analysed from 2017 to 2021. A mixed-effects model with a Poisson link function was fitted to evaluate the city-level annual changes in risk-adjusted incidence of anaesthesia-related deaths. Findings: 600 cases of anaesthetic deaths occurred from 2017 to 2021, yielding an incidence of 6.4 per 100,000 anaesthesia procedures [95% confidence interval (95% CI): 5.9, 6.9], and most were preventable (71.3%). There was a significant decrease from 2017 to 2021, in the incidences of anaesthesia-related death across all patients, those with American Society of Anaesthesiologists physical status (ASAPS) ≥III, and those who had general anae...