Altered large‐scale individual‐based morphological brain network in spinocerebellar ataxia type 3

作者：Shu Su, Runhua Sha, Haishan Qiu, Jianping Chu, Liping Lin, Long Qian, Manshi Hu, Chao Wu, Gerald L. Cheung, Zhiyun Yang, Yingqian Chen, Jing Zhao · 发表于：CNS Neuroscience & Therapeutics · 年份：2023 · DOI：10.1111/cns.14332 · 被引用次数：13 · 研究领域：Genetic Neurodegenerative Diseases、Functional Brain Connectivity Studies、Vestibular and auditory disorders

Abstract Background Accumulating evidences indicate regional gray matter (GM) morphology atrophy in spinocerebellar ataxia type 3 (SCA3); however, whether large‐scale morphological brain networks (MBNs) undergo widespread reorganization in these patients remains unclear. Objective To investigate the topological organization of large‐scale individual‐based MBNs in SCA3 patients. Methods The individual‐based MBNs were constructed based on the inter‐regional morphological similarity of GM regions. Graph theoretical analysis was taken to assess GM structural connectivity in 76 symptomatic SCA3, 24 pre‐symptomatic SCA3, and 54 healthy normal controls (NCs). Topological parameters of the resulting graphs and network‐based statistics analysis were compared among symptomatic SCA3, pre‐symptomatic SCA3, and NCs groups. The inner association between network properties and clinical variables was further analyzed. Results Compared to NCs and pre‐symptomatic SCA3 patients, symptomatic SCA3 indicated significantly decreased integration and segregation, a shift to “weaker small‐worldness”, characterized by decreased C p , lower E loc, and E glob (all p < 0.005). Regarding nodal properties, symptomatic SCA3 exhibited significantly decreased nodal profiles in the central executive network (CEN)‐related left inferior frontal gyrus, limbic regions involving the bilateral amygdala, left hippocampus, and bilateral pallidum, thalamus; and increased nodal degree, efficiency in bilateral caudate ...