Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK

作者：Benjamin D. McNair, Sydney M. Polson, Samantha K. Shorthill, Aykhan Yusifov, Lori A. Walker, Mary C.M. Weiser‐Evans, Elizabeth J. Kovacs, Danielle R. Bruns · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2023 · DOI：10.1152/ajpheart.00124.2023 · 被引用次数：9 · 研究领域：Pulmonary Hypertension Research and Treatments、Cardiovascular Function and Risk Factors、Cardiac Fibrosis and Remodeling

Right ventricular (RV) function predicts survival in age-related disease, yet mechanisms of RV failure are unclear. We show that aged mice undergo exacerbated RV remodeling compared with young. We tested the AMPK activator metformin to improve RV function and show that metformin attenuates RV remodeling only in adult male mice via a mechanism that does not require cardiac AMPK. Metformin is therapeutic for RV dysfunction in an age- and sex-specific manner independent of cardiac AMPK.