PNIPAm Thermo-Responsive Nanofibers Mats: Morphological Stability and Response Behavior under Cross-Linking

作者：Xiaojing Tian, Zhichun Huang, Qingsong Zhang, Xu Wang, Ning Yang, Nanping Deng · 发表于：Acta Physico-Chimica Sinica · 年份：2023 · DOI：10.3866/pku.whxb202304037 · 被引用次数：8 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Conducting polymers and applications、Graphene and Nanomaterials Applications

Since 2004, poly( N -isopropylacrylamide) (PNIPAm) cross-linked thermoresponsive nanofibers mats have emerged as a responsive material with a phase transition temperature that can be easily controlled. These mats overcome the limitations, such as a high production cost and slow response rate, of huge traditional PNIPAm hydrogels. They also overcome the poor water resistance of PNIPAm noncross-linked thermo-responsive nanofibers and, thus, have been widely studied. In 2017, continuous PNIPAm thermo-responsive nanofibers in pure aqueous solvents without beads were fabricated, which began the ecological and water-based era of uniform PNIPAm nanofiber production. In this review, we comprehensively analyzed the effects of physical and chemical cross-linking reaction types, cross-linking degree, cross-linking time, and cross-linking molecular weight on the morphological stability and response behavior of PNIPAm thermo-responsive nanofibers mats , providing theoretical support for their future crosslinking treatment. Because of their high specific surface area and porosity, PNIPAm thermo-responsive nanofibers mats are vulnerable to solvent erosion before cross-linking, which damage their morphology and reduce response rates and usage times. Increased water resistance and can be utilized repeatedly, by introducing cross-linking groups to these mats, such as in drug release, cell culture, drivers, and smart switches. Chemical cross-linking are more stable than physical cross-linking a...