[Mechanism of intestinal injury induced by WNT2B high-expressed fibroblasts in Crohn's disease].

作者：Yeung‐Leung Cheng, Shuang-Yan Xiao, D Q Liu, L L Geng, Jianjun Gu, Renkuan Tang, L Lan, Yun Zhu, P Y Chen, Zhimin He, Sitang Gong, Yanling Cheng · 发表于：PubMed · 年份：2023 · DOI：10.3760/cma.j.cn112140-20221202-01022 · 研究领域：Inflammatory Bowel Disease、IL-33, ST2, and ILC Pathways

WNT2B high-expressed fibroblasts can secrete WNT2B protein and activate the Wnt classical signaling pathway thus enhancing the expression and secretion of CXCL12 in macrophages, inducing the development of intestinal inflammation of Crohn's disease.