Switchable Direct Oxygenative Arylation of C(sp 3 )–H Bonds via Electrophotocatalysis

作者：Yan Zhang, Xiang Sun, Ji‐Hu Su, Tong Li, Chengbin Du, Kuiliang Li, Qi Sun, Zhenggen Zha, Zhiyong Wang · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c01751 · 被引用次数：24 · 研究领域：Catalytic C–H Functionalization Methods、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

A metal-free electrophotochemical C(sp 3 )-H arylation was developed under mild conditions. This method enables a switchable synthesis of diaryl alcohols and diaryl alkanes from inactive benzylic carbons. More importantly, a cheap and safe mediator N -chlorosuccinimide (NCS) was developed, which was employed for the hydrogen atom transfer (HAT) process of the benzylic C–H bond. In addition, this active radical was captured and identified by electron paramagnetic resonance (EPR).