Trends in Disparities and Transitions of Treatment in Patients With Early Breast Cancer in China and the US, 2011 to 2021

作者：Jianbin Li, Jifang Zhou, Haibo Wang, Zhenzhen Liu, Zhimin Fan, Yinhua Liu, Cuizhi Geng, Yue Xiao, Zefei Jiang, Yunjiang Liu, Yuhua Song, Min Yan, Qianjun Chen, Ying Lin, Qiang Liu, Feng Jin, Yuee Teng, Peifen Fu, Jianguo Zhang, Zhigao Li, Yiding Chen, Kun Wang, Yongmei Yin, Xiaoming Zha, Haiqing Zhang · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.21388 · 被引用次数：32 · 研究领域：Breast Cancer Treatment Studies、Advanced Breast Cancer Therapies、Global Cancer Incidence and Screening

Importance: Breast cancer treatment has profoundly improved in China recently. However, trends in disparities and transitions of treatment in early-stage cancer between China and the US are not well known. Objective: To identify changes for patients with early breast cancer by using large databases from China and the US. Design, Setting, and Participants: This multicenter cross-sectional study used the Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) database from hospitals in 13 provinces in China and the Flatiron Health (hereinafter referred to as Flatiron) database from more than 280 community oncology clinics in the US. Patients with stage I to III breast cancer diagnosed from January 1, 2011, to December 31, 2021, were included. Data were analyzed from June 10 to December 1, 2022. Main Outcomes and Measures: The distribution of age, clinical stage, and cancer subtypes at diagnosis were examined overall and by year. The mean annual percent change (MAPC) from 2011 to 2021 in systemic therapy and surgery was also analyzed. Results: A total of 57 720 patients with early breast cancer were screened from the CSCO BC (n = 45 970) and Flatiron (n = 11 750) databases. The median age at diagnosis in China among the 41 449 patients included in the age analysis was 47 (IQR, 40-56) years; in the US, the median age was 64 (IQR, 54-73) years. Among patients with clinical stage data in the CSCO BC (n = 22 794) and Flatiron (n = 4413) databases, the proportion of stage I canc...