Global Research Trends of Exosomes in the Central Nervous System: A Bibliometric and Visualized Analysis

作者：Yue Zhuo, Kun Ai, Ke He, Boyu Wu, Jiaying Peng, Jing Xiang, Guanlin Zhang, Ziyuan Jiao, R N Zhou, Hong Zhang · 发表于：Neurospine · 年份：2023 · DOI：10.14245/ns.2244988.494 · 被引用次数：7 · 研究领域：Extracellular vesicles in disease、Long-Term Effects of COVID-19、MicroRNA in disease regulation

OBJECTIVE: Exosomes in the central nervous system (CNS) have become an attractive area of research with great value. However, few bibliometric analysis has been conducted. The study aimed to visualize the scientific trends and research hotspots of exosomes in the CNS by bibliometric analysis. METHODS: All potential articles and reviews on exosomes in the CNS published in English from 2001 to 2021 were extracted from the Web of Science Core Collection. The visualization knowledge maps of critical indicators, including countries/regions, institutions, authors, journals, references, and keywords, were generated by CiteSpace and VOSviewer software. Besides, each domain's quantitative and qualitative analysis was also considered. RESULTS: A total of 2,629 papers were included. The number of exosomes-related publications and citations regarding CNS increased yearly. These publications came from 2,813 institutions in 77 countries/regions, led by the United States and China. Harvard University was the most influential institution, while the National Institutes of Health was the most critical funding source. We identified 14,468 authors, among which Kapogiannis D had the most significant number of articles and the highest H-index, while Théry C was the most frequently co-cited. The cluster analysis of keywords generated 13 clusters. In summary, the topic of biogenesis, biomarker, and drug delivery will serve as hotspots in future research. CONCLUSION: Exosomes-related CNS research has...