The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies

作者：Xin-yun Gou, Yuxi Li, Liu-xue Guo, Jing Zhao, Dongling Zhong, Xiaobo Liu, Haisha Xia, Jin Fan, Yue Zhang, Shuangchun Ai, Jiaxi Huang, Hongru Li, Juan Li, Rongjiang Jin · 发表于：Frontiers in Psychiatry · 年份：2023 · DOI：10.3389/fpsyt.2023.1099426 · 被引用次数：28 · 研究领域：Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Emotion and Mood Recognition、Neural and Behavioral Psychology Studies

Background Depression is generally accompanied by a disturbed conscious processing of emotion, which manifests as a negative bias to facial/voice emotion information and a decreased accuracy in emotion recognition tasks. Several studies have proved that abnormal brain activation was responsible for the deficit function of conscious emotion recognition in depression. However, the altered brain activation related to the conscious processing of emotion in depression was incongruent among studies. Therefore, we conducted an activation likelihood estimation (ALE) analysis to better understand the underlying neurophysiological mechanism of conscious processing of emotion in depression. Method Electronic databases were searched using the search terms “depression,” “emotion recognition,” and “neuroimaging” from inceptions to April 10th, 2023. We retrieved trials which explored the neuro-responses of depressive patients to explicit emotion recognition tasks. Two investigators independently performed literature selection, data extraction, and risk of bias assessment. The spatial consistency of brain activation in conscious facial expressions recognition was calculated using ALE. The robustness of the results was examined by Jackknife sensitivity analysis. Results We retrieved 11,365 articles in total, 28 of which were included. In the overall analysis, we found increased activity in the middle temporal gyrus, superior temporal gyrus, parahippocampal gyrus, and cuneus, and decreased act...