Prevalence of neutropenia in US residents: a population based analysis of NHANES 2011–2018

作者：Jing Zhou, Nan Zhou, Qing Liu, Zhiping Xie, Yun Xu, Si-Cheng Dai, Juan Lu, Zheng-Yang Bao, Li‐Da Wu · 发表于：BMC Public Health · 年份：2023 · DOI：10.1186/s12889-023-16141-5 · 被引用次数：17 · 研究领域：Blood disorders and treatments、Neutropenia and Cancer Infections、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Abstract Aims Neutrophils play a pivotal in immunity and inflammation. We aim to investigate the prevalence of neutropenia in the United States. Methods In this cross-sectional study, participants from the National Health and Nutrition Examination Survey (NHANES) (2011–2018) were enrolled. Demographic information, hematologic measurements, smoking status of all participants were collected for all participants. All statistical analyses were performed utilizing the NHANES survey weights. Covariate-adjusted linear regression was used to compare hematologic indices in different population grouped by age, sex, ethnicity, and smoking. We also employed multivariate-logistic regression to estimate the weighted odds ratio with a 95% confidence interval and predict the neutropenia risk among. Results 32,102 participants from NHANES survey were included, represented 286.6 million multiracial population in the United States. Black participants had lower mean leukocyte count (mean difference (MD): 0.71 × 10 9 /L; P < 0.001) and lower neutrophil count (MD: 0.83 × 10 9 /L; P < 0.001) compared with white participants after adjusting for age and sex. Furthermore, t a notable observation was the significant downward shift in the distribution curves of leukocyte count and neutrophil count among black participants. Smokers had a higher mean leukocyte count (MD: 1.10 × 10 9 cells/L; P < 0.001) and a higher mean neutrophil count (MD: 0.75 × 10 9 cells/L; P < 0.001) comparing with nonsm...