Cobalt/Rhodium-Catalyzed Diversified Amidation of Benzocyclobutenols via C–C Cleavage under Catalyst and Condition Control

作者：Xingwei Li, Runze Zhang, Zisong Qi, Junwei Li, Lingheng Kong · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c01788 · 被引用次数：11 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Asymmetric Hydrogenation and Catalysis

Cobalt(III) and rhodium(III)-catalyzed regio- and chemoselective amidation of benzocyclobutenols has been realized using dioxazolone as the amidating reagent to afford three classes of C–N-coupled products via β-carbon elimination of the benzocyclobutenol. The Co(III)-catalyzed coupling initially afforded an isolable o -( N -acylamino)arylmethyl ketone, which could further cyclize to the corresponding indole derivatives under condition control. In contrast, efficient stepwise diamidation has been achieved under Rh(III) catalyst control. The chemoselectivities are jointly controlled by the catalyst and reactions conditions.