Compositional alterations of the gut microbiota in acute myocardial infarction patients with type 2 diabetes mellitus

作者：Chao Lei, Xiaoming Zhang, Enyue Chen, Ludan Lin, Zhou Zhou, Zhimo Wang, Ting Liu, Zhihua Liu · 发表于：Annals of Translational Medicine · 年份：2023 · DOI：10.21037/atm-22-3521 · 被引用次数：14 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Adipokines, Inflammation, and Metabolic Diseases

Background: Type 2 diabetes mellitus (T2DM) is a risk factor for acute myocardial infarction (AMI) and a common comorbidity in patients with AMI. T2DM doubles the fatality rate of patients with AMI in the acute phase of AMI and the follow-up period. However, the mechanisms by which T2DM increases the fatality rate remain unknown. This study sought to investigate changes in the gut microbiota of patients with AMI and T2DM (AMIDM) to extend understandings of the relative mechanisms from the aspects of gut microbiota. Methods: Patients were recruited and divided into 2 groups comprising 15 patients with AMIDM and 15 patients with AMI but without T2DM (AMINDM). Their stool samples and clinical information were collected. 16S ribosomal DNA sequencing was used to analyze the structure and composition of the gut microbiota based on the operational taxonomic units. Results: A significant difference was observed in the gut microbiota β diversity between the 2 groups. At the phylum level, the AMIDM patients showed an increase in the abundance of Firmicutes and a decrease in the abundance of Bacteroidetes compared to the AMINDM patients. At the genus level, the AMIDM patients showed an increase in the abundance of Companilactobacillus, Defluvitaleaceae UCG-011 and UCG-009, and a decrease in the abundance of Phascolarctobacterium and CAG 56 compared to the AMINDM patients. At the species level, the AMIDM patients showed an increase in the abundance of species unclassified NK4A214 group, ...