Risk factors and predictors of urogenous sepsis after percutaneous nephrolithotomy for idiopathic calcium oxalate nephrolithiasis

作者：Xinfeng Chen, Siqi Li, Chunmei Shi, Wei Zhang, Zhenmin Liu, Jie Jiang, Yong Zhang, Chen Zhan, Bing Zheng, Hua Zhu · 发表于：Translational Andrology and Urology · 年份：2023 · DOI：10.21037/tau-23-219 · 被引用次数：9 · 研究领域：Kidney Stones and Urolithiasis Treatments、Urinary Tract Infections Management、Paleopathology and ancient diseases

Background: The aim of this study was to use bioinformatics approaches to screen and identify the key genes of idiopathic calcium oxalate nephrolithiasis, and explore its potential molecular mechanism. Methods: The GSE73680 kidney stone data set was downloaded from the Gene Expression Omnibus (GEO). R software (The R Foundation for Statistical Computing) was used to screen differentially expressed genes. GeneMANIA and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) databases were used to analyze related genes interacting with crucial genes, and a protein-protein interaction (PPI) network was constructed. The differential genes were then subjected to the Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) database. The clinical data of 156 patients who received percutaneous nephrolithotomy (PCNL) therapy at our facility between January 2013 and December 2017 were retrospectively analyzed. The various parameters associated with postoperative urogenous sepsis were identified using multivariable logistic regression analysis. Results: expression 3 hours after surgery were all independently associated with the urosepsis development. Conclusions: in renal papillary tissue are more likely to cause the urinary source of idiopathic calcium oxalate nephrolithiasis after PCNL urogenous sepsis. These parameter...