The global burden of neglected zoonotic diseases: Current state of evidence

作者：Carlotta Di Bari, Narmada Venkateswaran, Christina Fastl, Sarah Gabriël, Delia Grace, Arie H. Havelaar, Ben Huntington, Grace Patterson, Jonathan Rushton, Niko Speybroeck, Paul R. Torgerson, David M. Pigott, Brecht Devleesschauwer · 发表于：One Health · 年份：2023 · DOI：10.1016/j.onehlt.2023.100595 · 被引用次数：63 · 研究领域：Zoonotic diseases and public health、Viral Infections and Vectors、Viral gastroenteritis research and epidemiology

The majority of emerging infectious diseases are zoonoses, most of which are classified as "neglected". By affecting both humans and animals, zoonoses pose a dual burden. The disability-adjusted life year (DALY) metric quantifies human health burden since it combines mortality and morbidity. This review aims to describe and analyze the current state of evidence on neglected zoonotic diseases (NZDs) burden and start a discussion on the current understanding of the global burden of NZDs. We identified 26 priority NZDs through consulting three international repositories for national prioritization exercises. A systematic review of global and national burden of disease (BoD) studies was conducted using pre-selected databases. Data on diseases, location and DALYs were extracted for each eligible study. A total of 1887 records were screened, resulting in 74 eligible studies. The highest number of BoD was found for non-typhoidal salmonellosis (23), whereas no estimates were found for West Nile, Marburg and Lassa fever. Geographically, the highest number of studies was performed in the Netherlands (11), China (5) and Iran (4). The number of BoD retrieved mismatched the perceived importance in national prioritization exercises. For example, anthrax was considered a priority NZD in 65 countries; however, only one national study estimating BoD was retrieved. By summing the available global estimates, the selected NZDs caused at least 21 million DALYs per year, a similar order of magnitu...