Cadherin Is a Binding Protein but Not a Functional Receptor of Bacillus thuringiensis Cry2Ab in Helicoverpa armigera

作者：Zaw Lin Naing, Ei Thinzar Soe, Caihong Zhang, Linlin Niu, Jinrong Tang, Zhongwei Ding, Siqi Yu, Jie Lu, Fengyun Fang, Gemei Liang · 发表于：Applied and Environmental Microbiology · 年份：2023 · DOI：10.1128/aem.00625-23 · 被引用次数：8 · 研究领域：Insect Resistance and Genetics、Insect Pest Control Strategies、Entomopathogenic Microorganisms in Pest Control

To improve the efficiency of production of a single toxin in crops and to delay the evolution of insect resistance to the toxin, the second generation of Bt cotton, expressing Cry1Ac and Cry2Ab, was introduced. Understanding the mode action of the Cry proteins in the insect midgut and the mechanisms insects use to overcome these toxins plays a crucial role in developing measures to counter them. Extensive studies have been conducted on the receptors of Cry1A toxins, but relatively little has been done about those of Cry2Ab. By showing the nonfunctional binding of cadherin protein with Cry2Ab, we have furthered the understanding of Cry2Ab receptors.