Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient

作者：Shiyu Zhang, Lu Lu, Jindi Feng, Zhonghui Hu, Hongbin Song, Lu Yang, Yuehua Liu, Di Chen, Tao Wang · 发表于：Journal of Dermatological Treatment · 年份：2023 · DOI：10.1080/09546634.2023.2229466 · 被引用次数：7 · 研究领域：Drug-Induced Adverse Reactions、Autoimmune Bullous Skin Diseases、Autoimmune and Inflammatory Disorders

Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after starting dupilumab treatment, which improved after reducing the dose, without discontinuing dupilumab. The patient also experienced asymptomatic hypereosinophilia, possibly related to dupilumab, which was gradually relieved without discontinuation. With the readers, we share our experience in managing uveitis and hypereosinophilia associated with dupilumab, which may be helpful in managing these conditions and avoiding discontinuation of dupilumab.