Visible‐Light Photoredox Catalyzed Regioselective 1,4‐Hydroalkylation of 1,3‐Enyne

作者：Hong Hou, Yingjie Pan, Yuejie Sun, Ying Han, Chao‐Guo Yan, Yaocheng Shi, Shaoqun Zhu · 发表于：Chemistry - A European Journal · 年份：2023 · DOI：10.1002/chem.202301633 · 被引用次数：21 · 研究领域：Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

Described herein is a visible-light photoredox-catalyzed regioselective 1,4-hydroalkylation of 1,3-enynes. Various of di- and tri-substituent allenes were really accessible under the present reaction conditions. The visible-light photoredox activation of the carbon nucleophile to generate its radical species, allowing the addition with un-activated enynes. The synthetic utility for the present protocol was demonstrated by a large-scale reaction, as well as the derivatization of the allene product.