[Clinical characteristics and prognostic factors of patients with Philadelphia-negative myeloproliferative neoplasm accelerated/blast phase].

作者：Xin Yan, T J Qin, B Li, S Q Qu, L J Pan, F H Li, N N Liu, Zhijian Xiao, Zefeng Xu · 发表于：PubMed · 年份：2023 · DOI：10.3760/cma.j.issn.0253-2727.2023.04.003 · 被引用次数：3 · 研究领域：Myeloproliferative Neoplasms: Diagnosis and Treatment、Kruppel-like factors research、Acute Myeloid Leukemia Research

The proportions of patients with PMF-AP/BP with splenomegaly, myelofibrosis grade ≥2, a higher LDH level, and a shorter duration from diagnosis to the transformation to AP/BP were higher than those of patients with other Philadelphia-negative MPN-AP/BP. The complex karyotype was an independent prognostic factor for OS. Compared with supportive therapy, AML-like therapy and allo-HSCT could prolong the OS of patients with MPN-AP/BP.