Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study

作者：Jun Xu, Lin Zhong, Huanzhang Shao, Qianqian Wang, Muhua Dai, Peng Shen, Yonghui Xiong, Weijun Zhang, Xutao Deng, Mingqiang Wang, Yue Zhu, Xindie Reng, Yongpo Jiang, Mengyuan Chen, Chengcong Zhu, Xueling Fang, Guojun He, Yijiao Han, Xiaohan Huang, Xuwei He, Yinghe Xu, Hongliu Cai, Lingtong Huang · 发表于：Critical Care · 年份：2023 · DOI：10.1186/s13054-023-04530-6 · 被引用次数：32 · 研究领域：Cytomegalovirus and herpesvirus research、Viral-associated cancers and disorders、Neutropenia and Cancer Infections

PURPOSE: The significance of detecting human herpesvirus 7 (HHV-7) in the lower respiratory tract of patients with severe pneumonia is unclear. This study aims to evaluate the clinical characteristics and prognosis of detecting HHV-7 in the lower respiratory tract of patients with severe pneumonia. METHODS: Patients with severe pneumonia requiring invasive mechanical ventilation and underwent commercial metagenomic next-generation sequencing (mNGS) testing of bronchoalveolar lavage fluid from January 2019 to March 2023 were enrolled in 12 medical centers. Clinical data of patients were collected retrospectively, and propensity score matching was used for subgroup analysis and mortality assessment. RESULTS: In a total number of 721 patients, 45 cases (6.24%) were identified with HHV-7 positive in lower respiratory tract. HHV-7 positive patients were younger (59.2 vs 64.4, p = 0.032) and had a higher rate of co-detection with Cytomegalovirus (42.2% vs 20.7%, p = 0.001) and Epstein-Barr virus (35.6% vs 18.2%, p = 0.008). After propensity score matching for gender, age, SOFA score at ICU admission, and days from ICU admission to mNGS assay, there was no statistically significant difference in the 28-day mortality rate between HHV-7 positive and negative patients (46.2% vs 36.0%, p = 0.395). Multivariate Cox regression analysis adjusting for gender, age, and SOFA score showed that HHV-7 positive was not an independent risk factor for 28-day mortality (HR 1.783, 95%CI 0.936-3.400, ...