Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis

作者：Peilun Li, Ziqing Liu, Kewen Wan, Kangle Wang, Zheng Chen, Junhao Huang · 发表于：Journal of Exercise Science & Fitness · 年份：2023 · DOI：10.1016/j.jesf.2023.06.002 · 被引用次数：16 · 研究领域：Cardiovascular Health and Disease Prevention、Cardiovascular and exercise physiology、Peripheral Artery Disease Management

Overweight and obese older adults have a high risk for developing cardiovascular disease. Aerobic exercise is a valuable strategy to improve vascular health, but the effects of aerobic exercise on vascular endothelial function in obese and overweight older adults remain controversial. The purpose of this meta-analysis was to investigate the effects of aerobic exercise on vascular function in obese and overweight older adults with or without comorbidity. A systematic literature search for related studies published in English was conducted between January 1989 and October 30, 2022, in the PubMed, Embase, and Cochrane Library databases. A random effects model was chosen for meta-analysis, which calculated the effect sizes of control and intervention groups after exercise intervention using standardized mean differences (SMDs) corrected for Hedges' g bias and 95% confidence intervals (95% CIs). Twenty-six studies containing 1418 participants were included in the study. After excluding three studies contributing to higher heterogeneity by sensitivity analysis, there are small effects of regular aerobic exercise on vascular function of obese and overweight older adults, including flow-mediated dilation (FMD) [SMD = 0.21, 95% CI (0.02, 0.41), z = 2.16, df = 19, I2 = 52.2%, P = 0.031] and pulse wave velocity (PWV) [SMD = −0.24, 95% CI (−0.46, −0.02), z = 2.17, df = 10, I2 = 8.6%, P = 0.030], and no significant effect was observed on augmentation index (Aix). Subgroup analysis showed ...