Fabrication of a colorimetric sensor using acetic acid-capped drug-mediated copper oxide nanoparticles for nitrite biosensing in processed food

作者：Umar Nishan, Sajida Rehman, Riaz Ullah, Ahmed Bari, Saifullah Afridi, Mohibullah Shah, Jibran Iqbal, Muhammad Asad, A. Badshah, Naeem Khan, In Min Hwang, Hameed Khan, Nawshad Muhammad · 发表于：Frontiers in Materials · 年份：2023 · DOI：10.3389/fmats.2023.1169945 · 被引用次数：11 · 研究领域：Advanced Nanomaterials in Catalysis、Electrochemical sensors and biosensors、Advanced biosensing and bioanalysis techniques

Nitrite (NO 2 − ) and nitrate (NO 3 − ) are frequently used in cured meat products as preservatives, as they give a better taste and work well in color fixation. As a key possible carcinogen, excessive dietary consumption of NO 2 − in cured meat products would be bad for health. Herein, copper oxide nanoparticles (CuO NPs) were synthesized using the drug Augmentin as a reducing and capping agent. The desired synthesis of CuO NPs was confirmed by various characterization techniques, including UV–visible spectroscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, thermal gravimetric analysis, X-ray diffraction, and scanning electron microscopy. The new approach of drug-mediated acetic acid-capped CuO NPs was developed for simple colorimetric detection of nitrite ions in a mimic solution of processed food. The color of the detection system changes from brown to yellow with the increase in the concentration of NO 2 − and has been observed with the naked eye. The selectivity of the NO 2 − detection system by the UV–visible spectrum and the naked eye is compared to other ions, such as Br − , I − , Cl −1 , PO 4 −3 , CO 3 2− , and SO 4 2− . The platform was successfully employed for the determination of nitrite in real samples. Moreover, this probe can be used for the sensitive detection of NO 2 − with a linear range of 1 × 10 −8 to 2.40 × 10 −6 M, a detection limit of 2.69 × 10 −7 M, a limit of quantification 8.9 × 10 −7 M, and a regression coefficie...