Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability

作者：Zhiqiang Wang, Xia-Lin Dai, Dai-Lin Gu, Chao Wu, Tong‐Bu Lu, Xiangtian Long, Jia‐Mei Chen · 发表于：CrystEngComm · 年份：2023 · DOI：10.1039/d3ce00473b · 被引用次数：11 · 研究领域：Crystallography and molecular interactions、Crystallization and Solubility Studies、Enzyme Structure and Function

Cocrystallization of two anti-melanoma drugs, lenvatinib and temozolomide, resulted in two drug–drug cocrystal solvates presenting improved performance in terms of stability, dissolution, and tabletability, which show great potential to be developed as a drug combination.