Hormonal and inflammatory signatures of different mood episodes in bipolar disorder: a large-scale clinical study

作者：Nan Lyu, Qian Zhao, Bingbing Fu, Jinhong Li, Han Wang, Fan Yang, Sitong Liu, Juan Huang, Xinwei Zhang, Ling Zhang, Rena Li · 发表于：BMC Psychiatry · 年份：2023 · DOI：10.1186/s12888-023-04846-1 · 被引用次数：27 · 研究领域：Bipolar Disorder and Treatment、Tryptophan and brain disorders、Phosphodiesterase function and regulation

BACKGROUND: Bipolar disorder (BD) is characterized by intensive mood fluctuations. While hormones imbalance plays important role in the mood swings, it is unknown whether peripheral hormones profiles could differentiate the manic and depressive mood episodes in BD. In this study, we investigated the changes of various hormones and inflammatory markers across distinct mood episodes of BD in a large clinical study to provide mood episode-specific peripheral biomarkers for BD. METHODS: A total of 8332 BD patients (n = 2679 depressive episode; n = 5653 manic episode) were included. All patients were in acute state of mood episodes and need hospitalization. A panel of blood tests were performed for levels of sex hormones (serum levels of testosterone, estradiol, and progesterone), stress hormones (adrenocorticotropic hormone and cortisol), and an inflammation marker (C-reactive protein, CRP). A receiver operating characteristic (ROC) curve was used to analyze the discriminatory potential of the biomarkers for mood episodes. RESULTS: In overall comparison between mood episodes, the BD patients expressed higher levels of testosterone, estradiol, progesterone, and CRP (P < 0.001) and lower adrenocorticotropic hormone (ACTH) level (P < 0.001) during manic episode. The episode-specific changes of testosterone, ACTH, and CRP levels remained between the two groups (P < 0.001) after correction for the confounding factors including age, sex, BMI, occupation, marital status, tobacco use, al...