Clinical evidence of the efficacy and safety of a new multi‐peptide anti‐aging topical eye serum

作者：Fengzhu Li, Haowei Chen, Dongxiao Chen, Bingjie Zhang, Qingying Shi, Xihong He, Huabing Zhao, Fang Wang · 发表于：Journal of Cosmetic Dermatology · 年份：2023 · DOI：10.1111/jocd.15849 · 被引用次数：12 · 研究领域：Skin Protection and Aging、Advancements in Transdermal Drug Delivery、melanin and skin pigmentation

BACKGROUND: Skin aging is a complex multifactorial progressive process. With age, intrinsic and extrinsic factors cause the loss of skin elasticity, with the formation of wrinkles, resulting in skin sagging through various pathways. A combination of multiple bioactive peptides could be used as a treatment for skin wrinkles and sagging. OBJECTIVES: This study aimed to evaluate the cosmetic efficacy of a multi-peptide eye serum as a daily skin-care product for improving the periocular skin of women within the ages of 20-45 years. METHODS: The stratum corneum skin hydration and skin elasticity were assessed using a Corneometer CM825 and Skin Elastometer MPA580, respectively. The PRIMOS CR technique based on digital strip projection technology was used for skin image and wrinkle analysis around the "crow's feet" area. Self-assessment questionnaires were filled on Day 14 and 28 of product use. RESULTS: This study included 32 subjects with an average age of 28.5 years. On Day 28, there was a significant decrease in the number, depth, and volume of wrinkles. Skin hydration, elasticity, and firmness increased continuously during the study period, consistent with typical anti-aging claims. A majority of the participants (75.00%) expressed overall satisfaction with their skin appearance after using the product. Most participants noted a visible skin improvement, with an increase in skin elasticity and smoothness, and confirmed the extensibility, applicability, and temperance of the pro...