Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway

作者：Zhengjian Wang, Jin Liu, Fan Li, Shurong Ma, Liang Zhao, Peng Ge, Haiyun Wen, Yibo Zhang, Xiaojun Liu, Yalan Luo, Jiaqi Yao, Guixin Zhang, Hailong Chen · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.03664-22 · 被引用次数：58 · 研究领域：Pancreatitis Pathology and Treatment、Pancreatic and Hepatic Oncology Research、Childhood Cancer Survivors' Quality of Life

). In addition, The AMPK/NF-κB/NLRP3 pathway mediated by SCFAs along the gut-lung axis may play an essential role in preventing the pathogenesis of SAP-ALI, which allows for reduced systemic inflammation and restoration of the intestinal barrier.