Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases

作者：Jing Xu, Yicheng Yang, Yicheng Yang, Xin Li, Shusi Ding, Lemin Zheng, Changming Xiong, Yuejin Yang, Yuejin Yang · 发表于：iMeta · 年份：2023 · DOI：10.1002/imt2.124 · 被引用次数：44 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Tryptophan and brain disorders

Abstract Cardiovascular diseases (CVDs) continue to be a significant contributor to global mortality, imposing a substantial burden and emphasizing the urgent need for disease control to save lives and prevent disability. With advancements in technology and scientific research, novel mechanisms underlying CVDs have been uncovered, leading to the exploration of promising treatment targets aimed at reducing the global burden of the disease. One of the most intriguing findings is the relationship between CVDs and gut microbiota, challenging the traditional understanding of CVDs mechanisms and introducing the concept of the gut‐heart axis. The gut microbiota, through changes in microbial compositions and functions, plays a crucial role in influencing local and systemic effects on host physiology and disease development, with its metabolites acting as key regulators. In previous studies, we have emphasized the importance of specific metabolites such as betaine, putrescine, trimethylamine oxide, and N,N,N‐trimethyl‐5‐aminovaleric acid in the potential treatment of CVDs. Particularly noteworthy is the gut microbiota‐associated metabolite succinate, which has garnered significant attention due to its involvement in various pathophysiological pathways closely related to CVDs pathogenesis, including immunoinflammatory responses, oxidative stress, and energy metabolism. Furthermore, we have identified succinate as a potential biomarker, highlighting its therapeutic feasibility in managi...