Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review

作者：Weimei Ou, Bin Wang, Guoming Zhang, Licheng Ding, Zhixian Liu, Kaimin Wu, Guangfeng Sun, Chengmin Huang, Zhaokai Li, Shuyuan Feng, Rui Gao · 发表于：Frontiers in Cardiovascular Medicine · 年份：2023 · DOI：10.3389/fcvm.2023.1123385 · 被引用次数：12 · 研究领域：SARS-CoV-2 and COVID-19 Research、Viral Infections and Immunology Research、Food Allergy and Anaphylaxis Research

A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) is a kind of rare adverse event after COVID-19 vaccination. Herein, we present a case of an 83-year-old male who suffered cold sweat ten minutes after the first inactivated COVID-19 vaccination and AMI one day later. The emergency coronary angiography showed coronary thrombosis and underlying stenosis in his coronary artery. Type II Kounis syndrome might be a potential mechanism, which is manifested as coronary thrombosis secondary to allergic reactions in patients with underlying asymptomatic coronary heart disease. We also summarize the reported AMI cases post COVID-19 vaccination, as well as overview and discuss the proposed mechanisms of AMI after COVID-19 vaccination, thus providing insights for clinicians to be aware of the possibility of AMI following COVID-19 vaccination and potential underlying mechanisms.