Alteration of intestinal microbiota is associated with diabetic retinopathy and its severity: Samples collected from southeast coast Chinese

作者：Xuemei Gu, Chaoyin Lu, Jian Pan, Jianzhong Ye, Qihan Zhu · 发表于：World Journal of Diabetes · 年份：2023 · DOI：10.4239/wjd.v14.i6.862 · 被引用次数：12 · 研究领域：Gut microbiota and health、Retinal Diseases and Treatments、Immune responses and vaccinations

OBJECTIVEdTo examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes.RESEARCH DESIGN AND METHODSdA pooled analysis using individual participant data from population-based studies around the world was performed.A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs.Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors.Pooled prevalence estimates were directly age-standardized to the 2010 World Diabetes Population aged 20-79 years.RESULTSdA total of 35 studies provided data from 22,896 individuals with diabetes.The overall prevalence was 34.6% (95% CI 34.5-34.8)for any DR, 6.96% (6.87-7.04)for proliferative DR, 6.81% (6.74-6.89)for diabetic macular edema, and 10.2% (10.1-10.3)for VTDR.All DR prevalence end points increased with diabetes duration, hemoglobin A 1c , and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes.CONCLUSIONSdThere are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide.Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR.These data highlight the su...