ESHRE good practice recommendations on recurrent implantation failure

作者：ESHRE Working Group on Recurrent Implantation Failure, Danilo Cimadomo, María José de los Santos, Georg Griesinger, George T. Lainas, Nathalie Le Clef, David J. McLernon, Debbie Montjean, Bettina Tóth, Nathalie Vermeulen, Nicholas S Macklon · 发表于：Human Reproduction Open · 年份：2023 · DOI：10.1093/hropen/hoad023 · 被引用次数：227 · 研究领域：Reproductive System and Pregnancy、Reproductive Biology and Fertility、Ovarian function and disorders

Abstract STUDY QUESTION How should recurrent implantation failure (RIF) in patients undergoing ART be defined and managed? SUMMARY ANSWER This is the first ESHRE good practice recommendations paper providing a definition for RIF together with recommendations on how to investigate causes and contributing factors, and how to improve the chances of a pregnancy. WHAT IS KNOWN ALREADY RIF is a challenge in the ART clinic, with a multitude of investigations and interventions offered and applied in clinical practice, often without biological rationale or with unequivocal evidence of benefit. STUDY DESIGN, SIZE, DURATION This document was developed according to a predefined methodology for ESHRE good practice recommendations. Recommendations are supported by data from the literature, if available, and the results of a previously published survey on clinical practice in RIF and the expertise of the working group. A literature search was performed in PubMed and Cochrane focussing on ‘recurrent reproductive failure’, ‘recurrent implantation failure’, and ‘repeated implantation failure’. PARTICIPANTS/MATERIALS, SETTING, METHODS The ESHRE Working Group on Recurrent Implantation Failure included eight members representing the ESHRE Special Interest Groups for Implantation and Early Pregnancy, Reproductive Endocrinology, and Embryology, with an independent chair and an expert in statistics. The recommendations for clinical practice were formulated based on the expert opinion of the working ...