Hemodynamic signal changes and functional connectivity in acute stroke patients with dysphagia during volitional swallowing: a pilot study

作者：Xin Wen, Junwei Peng, Yanying Zhu, Xiao Bao, Zihao Wan, Rongliang Hu, Huiyu Liu, Fang Li, Zicai Liu · 发表于：Medical Physics · 年份：2023 · DOI：10.1002/mp.16535 · 被引用次数：17 · 研究领域：Dysphagia Assessment and Management、Temporomandibular Joint Disorders、Optical Imaging and Spectroscopy Techniques

Abstract Background Dysphagia is one of the major post‐stroke complications, understanding post‐stroke changes in cortical excitability and promoting early remodeling of swallowing‐related cortical areas to enable accurate treatment is essential for recovery of patients. Objectives We aimed to investigate hemodynamic signal changes and functional connectivity in acute stroke patients with dysphagia compared to age‐matched healthy participants in response to volitional swallowing using functional near‐infrared spectroscopy (fNIRS) in this pilot study. Methods Patients with first‐ever post‐stroke dysphagia having an onset of 1–4 weeks and age‐matched right‐handed healthy subjects were recruited in our study. fNIRS with 47 channels was utilized to detect the oxyhemoglobin (HbO 2 ) and reduced hemoglobin (HbR) concentration changes when volitional swallowing. Cohort analysis was performed by a one‐sample t ‐test. Two‐sample t ‐test was utilized to compare the difference in cortical activation between patients with post‐stroke dysphagia and healthy subjects. Furthermore, the relative changes in the concentration of the HbO 2 throughout the experimental procedure were extracted for the functional connectivity analysis. The Pearson correlation coefficients of the HbO 2 concentration of each channel were analyzed on a time series, and then a Fisher Z transformation was then performed, and the transformed values were defined as the functional connection strengths between the channels....