Machine learning prediction of motor function in chronic stroke patients: a systematic review and meta-analysis

作者：Qinglin Li, Lei Chi, Weiying Zhao, Lei Wu, Chuanxu Jiao, Xue Zheng, Kaiyue Zhang, Xiaoning Li · 发表于：Frontiers in Neurology · 年份：2023 · DOI：10.3389/fneur.2023.1039794 · 被引用次数：9 · 研究领域：Artificial Intelligence in Healthcare and Education、Acute Ischemic Stroke Management、Radiomics and Machine Learning in Medical Imaging

Background: Recent studies have reported that machine learning (ML), with a relatively strong capacity for processing non-linear data and adaptive ability, could improve the accuracy and efficiency of prediction. The article summarizes the published studies on ML models that predict motor function 3-6 months post-stroke. Methods: A systematic literature search was conducted in PubMed, Embase, Cochorane and Web of Science as of April 3, 2023 for studies on ML prediction of motor function in stroke patients. The quality of the literature was assessed using the Prediction model Risk Of Bias Assessment Tool (PROBAST). A random-effects model was preferred for meta-analysis using R4.2.0 because of the different variables and parameters. Results: A total of 44 studies were included in this meta-analysis, involving 72,368 patients and 136 models. Models were categorized into subgroups according to the predicted outcome Modified Rankin Scale cut-off value and whether they were constructed based on radiomics. C-statistics, sensitivity, and specificity were calculated. The random-effects model showed that the C-statistics of all models were 0.81 (95% CI: 0.79; 0.83) in the training set and 0.82 (95% CI: 0.80; 0.85) in the validation set. According to different Modified Rankin Scale cut-off values, C-statistics of ML models predicting Modified Rankin Scale>2(used most widely) in stroke patients were 0.81 (95% CI: 0.78; 0.84) in the training set, and 0.84 (95% CI: 0.81; 0.87) in the valid...