Selection of Neisseria gonorrhoeae ceftriaxone resistance using doxycycline post-exposure prophylaxis

作者：David M. Whiley, Jacob A Tickner, Ratan Kundu, Tiffany R Hogan, Sebastiaan J. van Hal, Monica M Lahra · 发表于：The Lancet Infectious Diseases · 年份：2023 · DOI：10.1016/s1473-3099(23)00359-6 · 被引用次数：44 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、Bacterial Infections and Vaccines

There is increasing evidence that doxycycline post-exposure prophylaxis (doxy-PEP) is effective for preventing sexually transmitted infections among high-risk patients, particularly in patients using HIV pre-exposure prophylaxis.1–3 However, this benefit must be weighed against potential risks, including selection of antimicrobial resistance. Using whole genome sequencing data of 2375 gonococcal isolates from the 2018 Euro-GASP survey, Vanbaelen and colleagues4 showed that N gonorrhoeae tetracycline resistance-associated mutations and genes are often co-selected with additional antimicrobial resistance markers.