Years lived with disability of cancer in China: findings from disability weights measurement with a focus on the effect of disease burden

作者：Shaoyuan Lei, Rongshou Zheng, Shaokai Zhang, Yunchao Huang, Liang Qiao, BingBing Song, Yutong He, Lingbin Du, Ning Wang, Yunfeng Xi, Yuqin Liu, Jinyi Zhou, Min Zhang, Ying Zheng, Yong‐Zhen Zhang, Wen Ju, Wenqiang Wei · 发表于：中国科学通报：英文版 · 年份：2023 · DOI：10.1016/j.scib.2023.06.013 · 被引用次数：8 · 研究领域：Frailty in Older Adults、Global Cancer Incidence and Screening、Occupational and environmental lung diseases

Disability weights are crucial for quantifying health loss associated with non-fatal outcomes and were not well assessed in different countries, especially for specific cancer. Therefore, this study aimed to identify disability weights with a focus on specific cancer in a large Chinese population. Two types of web surveys were conducted, and 254 health states, including 30 new states for specific cancer, were investigated using paired comparison methods. The years lived with disability (YLDs) of cancer were calculated as the sum of the prevalence of each sequela of cancer multiplied by its relative disability weight. In total, 44,069 participants were eligible for the disability weights study. The disability weights of 254 health states were estimated. Among those, the disability weights of 18 specific cancer types varied greatly at diagnosis and primary treatment stage, with the value ranging from 0.619 (95% uncertainty interval (UI) 0.606-0.632) for brain cancer to 0.167 (95% UI 0.158-0.176) for oropharyngeal cancer. The discrepancy in YLDs calculated by different disability weights was high, and the largest gap for all cancer combined was approximately 30.14%. When calculated using the cancer-specific disability weights, a total of 1,967,830 (95% UI 1,928,880-2,008,060) YLDs of cancer were recorded in China. The disability weights of cancer varied greatly among cancer types and populations, which had considerable influence on the estimation of the disease burden. Cancer-sp...