Deep learning enhanced ultra-fast SPECT/CT bone scan in patients with suspected malignancy: quantitative assessment and clinical performance

作者：Na Qi, Boyang Pan, Qingyuan Meng, Yihong Yang, Tao Feng, Hui Liu, Nan‐Jie Gong, Jun Zhao · 发表于：Physics in Medicine and Biology · 年份：2023 · DOI：10.1088/1361-6560/acddc6 · 被引用次数：13 · 研究领域：Medical Imaging Techniques and Applications、Advanced X-ray and CT Imaging、Radiomics and Machine Learning in Medical Imaging

Abstract Objectives . To evaluate the clinical performance of deep learning-enhanced ultrafast single photon emission computed tomography/computed tomography (SPECT/CT) bone scans in patients with suspected malignancy. Approach . In this prospective study, 102 patients with potential malignancy were enrolled and underwent a 20 min SPECT/CT and a 3 min SPECT scan. A deep learning model was applied to generate algorithm-enhanced images (3 min DL SPECT). The reference modality was the 20 min SPECT/CT scan. Two reviewers independently evaluated general image quality, Tc-99m MDP distribution, artifacts, and diagnostic confidence of 20 min SPECT/CT, 3 min SPECT/CT, and 3 min DL SPECT/CT images. The sensitivity, specificity, accuracy, and interobserver agreement were calculated. The lesion maximum standard uptake value (SUV max ) of the 3 min DL and 20 min SPECT/CT images was analyzed. The peak signal-to-noise ratio (PSNR) and structure similarity index measure (SSIM) were evaluated. Main results . The 3 min DL SPECT/CT images showed significantly superior general image quality, Tc-99m MDP distribution, artifacts, and diagnostic confidence than the 20 min SPECT/CT images ( P < 0.0001). The diagnostic performance of the 20 min and 3 min DL SPECT/CT images was similar for reviewer 1 (paired X 2 = 0.333, P = 0.564) and reviewer 2 (paired X 2 = 0.05, P = 0.823). The diagnosis results for the 20 min (kappa = 0.822) and 3 min DL (kappa = 0.732) SPECT/CT images showed high interobserver...