Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

作者：Zhengtian Lyu, Yongfei Hu, Yuming Guo, Dan Liu · 发表于：Bone Research · 年份：2023 · DOI：10.1038/s41413-023-00264-x · 被引用次数：198 · 研究领域：Bone Metabolism and Diseases、Vitamin D Research Studies、Oral microbiology and periodontitis research

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, including probiotics or antibiotics, have been found to affect bone remodeling. This review provides a comprehensive summary of recent research on the role of GM in regulating bone remodeling and seeks to elucidate the regulatory mechanism from various perspectives, such as the interaction with the immune system, interplay with estrogen or parathyroid hormone (PTH), the impact of GM metabolites, and the effect of extracellular vesicles (EVs). Moreover, this review explores the potential of probiotics as a therapeutic approach for OP. The insights presented may contribute to the development of innovative GM-targeted therapies for OP.