Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

作者：Mengsi Yu, Zhiying Wang, Dongmin Wang, Milikemu Aierxi, Zhanjun Ma, Yonggang Wang · 发表于：Journal of Neuroscience Research · 年份：2023 · DOI：10.1002/jnr.25221 · 被引用次数：96 · 研究领域：Spinal Cord Injury Research、Cardiac Ischemia and Reperfusion、Nitric Oxide and Endothelin Effects

Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central nervous system; it imposes great psychological and economic burdens on affected patients and their families. The dynamic balance between reactive oxygen species (ROS) and antioxidants is essential for maintaining normal cellular physiological functions. As important intracellular signaling molecules, ROS regulate numerous physiological activities, including vascular reactivity and neuronal function. However, excessive ROS can cause damage to cellular macromolecules, including DNA, lipids, and proteins; this damage eventually leads to cell death. This review discusses the mechanisms of oxidative stress in SCI and describes some signaling pathways that regulate oxidative injury after injury, with the aim of providing guidance for the development of novel SCI treatment strategies.