Fluorescein-guided surgery for high-grade glioma resection: a five-year-long retrospective study at our institute

作者：Xi Chen, Jinli Sun, Jianyao Mao, Yan Chen, LI Hui-juan, Zhongjie Shi, Zhangyu Li, Zhou Liwei, Yukui Li, Chen Sifang, Tan Guowei · 发表于：Frontiers in Oncology · 年份：2023 · DOI：10.3389/fonc.2023.1191470 · 被引用次数：9 · 研究领域：Glioma Diagnosis and Treatment、Cancer Research and Treatments、Neurofibromatosis and Schwannoma Cases

Objective This study investigates the extent of resection, duration of surgery, intraoperative blood loss, and postoperative complications in patients with high-grade glioma who received surgery with or without sodium fluorescein guidance. Methods A single-center retrospective cohort study was conducted on 112 patients who visited our department and underwent surgery between July 2017 and June 2022, with 61 in the fluorescein group and 51 in the non-fluorescein group. Baseline characteristics, intraoperative blood loss, surgery duration, resection extent, and postoperative complications were documented. Results The duration of surgery was significantly shorter in the fluorescein group than in the non-fluorescein group (P = 0.022), especially in patients with tumors in the occipital lobes (P = 0.013). More critically, the gross total resection (GTR) rate was significantly higher in the fluorescein group than in the non-fluorescein group (45.9% vs. 19.6%, P = 0.003). The postoperative residual tumor volume (PRTV) was also significantly lower in the fluorescein group than in the non-fluorescein group (0.40 [0.12-7.11] cm 3 vs. 4.76 [0.44-11.00] cm 3 , P = 0.020). Particularly in patients with tumors located in the temporal and occipital lobes (temporal, GTR 47.1% vs. 8.3%, P = 0.026; PRTV 0.23 [0.12-8.97] cm 3 vs. 8.35 [4.05-20.59] cm 3 , P = 0.027; occipital, GTR 75.0% vs. 0.0%, P = 0.005; PRTV 0.15 [0.13-1.50] cm 3 vs. 6.58 [3.70-18.79] cm 3 , P = 0.005). However, the two grou...