Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

作者：Shaoguang Li, Hongyuan Zhang, Man Zhu, Zhujun Kuang, Xun Li, Fan Xu, Siyuan Miao, Zishuo Zhang, Xiaoding Lou, Hui Li, Fan Xia · 发表于：Chemical Reviews · 年份：2023 · DOI：10.1021/acs.chemrev.1c00759 · 被引用次数：303 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、Electrochemical sensors and biosensors

Whole blood, as one of the most significant biological fluids, provides critical information for health management and disease monitoring. Over the past 10 years, advances in nanotechnology, microfluidics, and biomarker research have spurred the development of powerful miniaturized diagnostic systems for whole blood testing toward the goal of disease monitoring and treatment. Among the techniques employed for whole-blood diagnostics, electrochemical biosensors, as known to be rapid, sensitive, capable of miniaturization, reagentless and washing free, become a class of emerging technology to achieve the target detection specifically and directly in complex media, e.g., whole blood or even in the living body. Here we are aiming to provide a comprehensive review to summarize advances over the past decade in the development of electrochemical sensors for whole blood analysis. Further, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms.