Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

作者：Kaile Yue, Dashuang Sheng, Xinxin Xue, Lanlan Zhao, Guoping Zhao, Chuandi Jin, Lei Zhang · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.00904-23 · 被引用次数：29 · 研究领域：Epigenetics and DNA Methylation、Ferroptosis and cancer prognosis、Gut microbiota and health

The burgeoning field of oncobiome research declared that members of the intratumoral microbiome besides Helicobacter pylori existed in tumor tissues and participated in the occurrence and development of gastric cancer, and the methylation of host DNA may be a potential target of microbes and their metabolites. Current research focuses mostly on species composition, but the functional genes of the members of the microbiota are also key to their interaction with the host.