Exercise and epigenetic ages in older adults with myeloid malignancies

作者：Kah Poh Loh, Chandrika Sanapala, Marielle Jensen‐Battaglia, Anish Rana, Michael B. Sohn, Erin Watson, Nikesha J. Gilmore, Heidi D. Klepin, Jason H. Mendler, Jane L. Liesveld, Eric J. Huselton, Marissa LoCastro, Martha Susiarjo, Colleen Netherby-Winslow, AnnaLynn M. Williams, Karen Michelle Mustian, Paula M. Vertino, Michelle C. Janelsins · 发表于：European journal of medical research · 年份：2023 · DOI：10.1186/s40001-023-01145-z · 被引用次数：18 · 研究领域：Acute Myeloid Leukemia Research、Cancer-related cognitive impairment studies、Cancer survivorship and care

BACKGROUND: Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age. We explored (1) the associations of accelerated DNAm age with physical, psychological, and cognitive functions at baseline; (2) changes in DNAm age from baseline to post-intervention; and (3) the associations of changes in accelerated DNAm age with changes in functions from baseline to post-intervention. METHODS: ) with a mobile application over 2 cycles of chemotherapy (8-12 weeks). Patients completed measures of physical, psychological, and cognitive functions and provided blood samples for analyses of DNAm age at baseline and post-intervention. Paired t-tests or Wilcoxon signed rank tests assessed changes in DNAm ages, and Spearman's correlation assessed the relationships between accelerated ages and functions. RESULTS: We included 20 patients (mean age: 72 years, range 62-80). Accelerated GrimAge, accelerated PhenoAge, and DunedinPACE were stable from baseline to post-intervention. At baseline, DunedinPACE was cor...