Modulation Effects of the CEP128 Gene on Radiotherapy‐Related Brain Injury: A Longitudinal Structural Study Using Multi‐Parametric Brain MR Images

作者：Shiwei Lin, Xiaofei Lv, Xiaoshan Lin, Shengli Chen, Yanqing Li, Manxi Xu, Yingwei Qiu, Lin‐Quan Tang · 发表于：Journal of Magnetic Resonance Imaging · 年份：2023 · DOI：10.1002/jmri.28824 · 被引用次数：7 · 研究领域：Brain Metastases and Treatment、Head and Neck Cancer Studies、Advanced Radiotherapy Techniques

BACKGROUND: The promoter variant rs17111237 in the CEP128 closely relates to radiotherapy (RT)-related brain necrosis in nasopharyngeal carcinoma (NPC) patients. PURPOSE: To explore RT-related dynamic alterations in brain morphology and their potential genetic mechanism, and to explore the modulatory effects of CEP128 genetic variants on RT-related brain morphological alterations in NPC patients. STUDY TYPE: Prospective, longitudinal. POPULATION: One hundred one patients with histopathologic ally-proven NPC (age 41.64 ± 9.63, 46 male), analyzed at baseline (pre-RT), 3-months post-RT and 6 months post-RT, and 19 sex-, age- and education-matched healthy controls. FIELD STRENGTH/SEQUENCE: 3D gradient echo brain volume (3D-BRAVO) and diffusion-weighted single-shot spin-echo echo-planar sequences at 3.0 T. ASSESSMENT: rs17111237 in CEP128 was detected by Sanger sequencing. Structural and diffusion images were processed with FreeSurfer and FSL. Morphometric similarity network (MSN) was constructed with nine cortical indices derived from structural and diffusion images. STATISTICAL TESTS: One-way ANOVA, chi-square test. Pearson's correlation analysis was conducted to measure the relationship between CEP128 gene-expression level in human brain and MSN alterations. Repeated analysis of variance performed to assess group differences in MSN and the modulatory effects of the CEP128 gene within patients. Significance level: P < 0.05, false-discovery rate correction. RESULTS: RT-related si...