TRIM29 acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma

作者：Caifeng Yue, Yuanmin Qian, Chang Wang, Jiewei Chen, Jing Wang, Zifeng Wang, Xiang‐Bo Wan, Su‐Mei Cao, Jingde Zhu, Qian Tao, Min Yan, Quentin Liu · 发表于：Cancer Science · 年份：2023 · DOI：10.1111/cas.15852 · 被引用次数：6 · 研究领域：Epigenetics and DNA Methylation、MicroRNA in disease regulation、Autophagy in Disease and Therapy

Epigenetic alterations marked by DNA methylation are frequent events during the early development of nasopharyngeal carcinoma (NPC). We identified that TRIM29 is hypomethylated and overexpressed in NPC cell lines and tissues. TRIM29 silencing not only limited the growth of NPC cells in vitro and in vivo, but also induced cellular senescence, along with reactive oxygen species (ROS) accumulation. Mechanistically, we found that TRIM29 interacted with voltage-dependent anion-selective channel 1 (VDAC1) to activate mitophagy clearing up damaged mitochondria, which are the major source of ROS. In patients with NPC, high levels of TRIM29 expression are associated with an advanced clinical stage. Moreover, we detected hypomethylation of TRIM29 in patient nasopharyngeal swab DNA. Our findings indicate that TRIM29 depends on VDAC1 to induce mitophagy and prevents cellular senescence by decreasing ROS. Detection of aberrantly methylated TRIM29 in the nasopharyngeal swab DNA could be a promising strategy for the early detection of NPC.