The Potential of MSC-Based Cell-Free Therapy in Wound Healing—A Thorough Literature Review

作者：Hui Ma, Wing Sum Siu, Ping‐Chung Leung · 发表于：International Journal of Molecular Sciences · 年份：2023 · DOI：10.3390/ijms24119356 · 被引用次数：53 · 研究领域：Wound Healing and Treatments、Mesenchymal stem cell research、Electrospun Nanofibers in Biomedical Applications

A wound is an interruption of the normal anatomic structure and function of the skin, which is critical in protecting against foreign pathogens, regulating body temperature and water balance. Wound healing is a complex process involving various phases, including coagulation, inflammation, angiogenesis, re-epithelialization, and re-modeling. Factors such as infection, ischemia, and chronic diseases such as diabetes can compromise wound healing, leading to chronic and refractory ulcers. Mesenchymal stem cells (MSCs) have been used to treat various wound models due to their paracrine activity (secretome) and extracellular vehicles (exosomes) that contain several molecules, including long non-coding RNAs (lncRNAs), micro-RNAs (miRNAs), proteins, and lipids. Studies have shown that MSCs-based cell-free therapy using secretome and exosomes has great potential in regenerative medicine compared to MSCs, as there are fewer safety concerns. This review provides an overview of the pathophysiology of cutaneous wounds and the potential of MSCs-based cell-free therapy in each phase of wound healing. It also discusses clinical studies of MSCs-based cell-free therapies.