Immune response plays a role in Mycoplasma pneumoniae pneumonia

作者：Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang, Yi Du, Jing Wang, Huilin Li, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Changdi Xu, Yan Liu, Deyu Zhao, Yun Guo, Feng Liu · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1189647 · 被引用次数：86 · 研究领域：Pneumonia and Respiratory Infections、Gut microbiota and health、Microbial infections and disease research

Introduction: Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP. Methods: This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing. Results: The MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response. Discussion: The immune response plays a role in MPP, which may inform treatment strategies for MPP.